Status:
COMPLETED
The Immune Modulation of Bilateral Paravertebral Block and Propofol in Spine Surgery.
Lead Sponsor:
Alaa Mazy Mazy
Conditions:
Immune Suppression
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
General anesthesia has an important effect on inflammatory cytokines. Inhalational agents as isoflurane and sevoflurane attenuate immune function expressed by neutrophil chemoattractant-1 as well as i...
Detailed Description
Spine surgery is characterized by an elevation in levels of the inflammatory cytokines such as interleukin IL-6, IL-1β, and IL-17. These cytokines promote chemokine production and changes in cell phen...
Eligibility Criteria
Inclusion
- patients scheduled for primary fixation of posterior lumbar spine surgery.
- American Society of Anesthesia statuses I or II patients.
- Single or double level lumbar spine fixation.
- Fixed surgical team.
Exclusion
- Patient refusal or uncooperative Patient.
- History of allergy to any anesthetic agents will be used in the study.
- Local sepsis.
- Abnormal coagulation test results.
- Usage of antiplatelet therapy.
- Demyelinated neurological diseases as multiple sclerosis.
- Mental retardation, psychotropic drug consumption.
- Recurrent spine fixation.
- Severe coronary or peripheral artery disease.
- Severe cardiac disease, renal or hepatic failure.
Key Trial Info
Start Date :
January 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2020
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT03437213
Start Date
January 1 2018
End Date
September 1 2020
Last Update
September 18 2020
Active Locations (1)
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1
Mansoura University Hospital
Al Mansurah, Dakahlia Governorate, Egypt, 35516