Status:
RECRUITING
Mechanisms of Familial Pulmonary Fibrosis
Lead Sponsor:
Vanderbilt University Medical Center
Conditions:
Familial Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis
Eligibility:
All Genders
40-75 years
Brief Summary
This a prospective, longitudinal study of first-degree family members of patients diagnosed with familial interstitial pneumonia (FIP). FIP is the familial form of idiopathic pulmonary fibrosis (IPF),...
Detailed Description
Potential research subjects will be sent a questionnaire (modified version of the ATS-DLD-78 questionnaire) and study consent form. Individuals with no prior history of lung disease and a dyspnea scor...
Eligibility Criteria
Inclusion
- Eligibility Requirements:
- Bloodline members of an affected individual from a family in which two or more members of a family are known to have Idiopathic Interstitial Pneumonia (IIP) and who have no personal diagnosis of IIP or IPF
- Sibling or adult child of an affected individual
- Exclusion Criteria:
- Inability to understand the requirements of the study or be unwilling to provide written informed consent (as evidenced by signature on an informed consent document approved by the IRB).
- Inability to travel to Nashville for 1-2 outpatient visits and/or complete a written or online version of the Interstitial Lung Disease Questionnaire
- Age \< 40 or \>75 years old. If the affected relative was younger than 50 years old at the time of IIP diagnosis, potential subjects between age 18 and 40 years may participate when they are up to 10 years younger than the age at relative's diagnosis.
- Underlying disease with signs and symptoms that could be confused with IIP or IPF symptoms (i.e., rheumatoid arthritis or other connective tissue diseases, occupational lung disease, chemotherapy, etc.)
- Thought to be unsuitable for participation in the study in the opinion of the investigator
Exclusion
Key Trial Info
Start Date :
January 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 30 2030
Estimated Enrollment :
750 Patients enrolled
Trial Details
Trial ID
NCT03437486
Start Date
January 1 2009
End Date
January 30 2030
Last Update
December 31 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232