Status:
COMPLETED
Effects of Carnitine Supplementation on Liver and Muscle
Lead Sponsor:
University of Nottingham
Collaborating Sponsors:
Nottingham University Hospitals NHS Trust
National Institute for Health Research, United Kingdom
Conditions:
Non-Alcoholic Fatty Liver Disease
Insulin Resistance
Eligibility:
MALE
18-50 years
Phase:
NA
Brief Summary
It will be evaluated whether carnitine, a dietary supplement, reduces liver fat and improves metabolism in individuals who have a high concentration of fat within their liver. Participants will be giv...
Detailed Description
NAFLD occurs when too much fat accumulates in liver tissue. This can, over time, cause inflammation and scarring of the liver, eventually leading to chronic liver disease and cirrhosis. It is strongly...
Eligibility Criteria
Inclusion
- Elevated liver fat on screening abdominal ultrasound
- Capable of providing informed consent
- Non-vegetarian diet
- BMI \<40 kg/m2
- Weekly ethanol consumption \<21 units/week
- Negative non-invasive liver screen, including Hepatitis B and C serology, liver autoantibodies, transferrin saturation, α1-antitrypsin levels.
Exclusion
- Known history of cardiovascular disease
- Known diabetes mellitus
- Known psychiatric comorbidity
- Chronic kidney disease
- Surgery within 6 months prior to start of study
- Exposure to drugs known to influence hepatic steatosis (including steroids, statins, omega-3-fatty acids)
- Current smokers
- Contraindications to magnetic resonance scanning, including implanted ferrous material (implantable pacemakers or defibrillators), metallic ocular foreign bodies, ferromagnetic aneurysm clips or severe claustrophobia.
Key Trial Info
Start Date :
April 2 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2021
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT03439917
Start Date
April 2 2018
End Date
November 1 2021
Last Update
November 30 2021
Active Locations (1)
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1
David Greenfield Human Physiology Unit
Nottingham, Notts, United Kingdom, NG72UH