Status:
COMPLETED
Impact of a Procalcitonin Testing and Treatment Algorithm on Antibiotic Use and Outcomes in the Pediatric Intensive Care Unit
Lead Sponsor:
Vanderbilt University Medical Center
Collaborating Sponsors:
National Institutes of Health (NIH)
Conditions:
Sepsis
Procalcitonin
Eligibility:
All Genders
2-17 years
Phase:
NA
Brief Summary
The timely use of antibiotics can reduce morbidity and mortality associated with bacterial infections, particularly in the intensive care unit setting (ICU). Long courses of antibiotics, however, are ...
Detailed Description
The timely use of effective antibiotics can markedly reduce the morbidity and mortality associated with bacterial infections, particularly in the intensive care unit (ICU). However, in this setting, m...
Eligibility Criteria
Inclusion
- 18 years of age or younger
- Prescribed or administered antibiotics in the hospital less than or equal to 24 hours prior to enrollment
- Have parents or legal guardians who provide informed consent
- Provide assent (if \> 7 years of age)
Exclusion
- Are not prescribed antibiotics in the hospital
- Receive intravenous antibiotics within 7 days prior to identification for study enrollment
- Primary or secondary immune deficiency
- History of malignancy, bone marrow transplant or solid organ transplant
- A diagnosis of cystic fibrosis
- Neonates \< 34 weeks gestation
- Patients receiving treatment for endocarditis, osteomyelitis, meningitis, mediastinitis or other invasive infection, for which long duration of antibiotics is needed
- Do not provide informed consent/assent
Key Trial Info
Start Date :
February 12 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 11 2019
Estimated Enrollment :
271 Patients enrolled
Trial Details
Trial ID
NCT03440918
Start Date
February 12 2018
End Date
May 11 2019
Last Update
April 22 2020
Active Locations (1)
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1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232