Status:
COMPLETED
Olfactory Function and Delayed Neurocognitive Recovery
Lead Sponsor:
Shanghai 10th People's Hospital
Collaborating Sponsors:
Massachusetts General Hospital
Conditions:
Delayed Neurocognitive Recovery
Eligibility:
All Genders
65+ years
Phase:
NA
Brief Summary
To explore whether odor enrichment can reduce the risk of delayed neurocognitive recovery as an intervention strategy.
Detailed Description
Postoperative neurocognitive disorder, one of the most common postoperative complications in older adults, includes acute postoperative delirium, delayed neurocognitive recovery (within the 30 days re...
Eligibility Criteria
Inclusion
- were aged at least 65 years old;
- were expected a postoperative hospital stay of at least 7 days;
- had American Society of Anesthesiologist (ASA) class I to II;
- were native Mandarin speakers;
- had been referred for a total knee or hip replacement under general anesthesia.
Exclusion
- were prior diagnosed of neurologic diseases by the International Statistical Classification of Diseases and Related Health Problems, 10th Revision (ICD-10);
- had a history of mental disorders diagnosed using the Diagnostic and Statistical Manual of Mental Disorders (DSM-5);
- had a history of illness or surgery with nasal or sinus;
- caught cold within one week;
- impaired vision or auditory function which may affect the assessments;
- were unwilling to comply with the protocol or procedures;
- did not pass the Mini-mental State Examination (illiterates get less than 18 points, primary school graduates get less than 20 points, secondary school graduates or higher get less than 24 points) .
Key Trial Info
Start Date :
January 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2022
Estimated Enrollment :
131 Patients enrolled
Trial Details
Trial ID
NCT03441074
Start Date
January 1 2018
End Date
December 31 2022
Last Update
July 31 2025
Active Locations (1)
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1
Shanghai Tenth People's Hospital
Shanghai, Shanghai Municipality, China, 200072