Status:
UNKNOWN
Mechanisms of Alcohol Sensitivity in AERD
Lead Sponsor:
University of Virginia
Conditions:
Aspirin-Sensitive Asthma With Nasal Polyps
Samter's Syndrome
Eligibility:
All Genders
21+ years
Phase:
NA
Brief Summary
The purpose of this study is to determine what type of reactions in the body may be responsible for the respiratory symptoms that occur when patients with Aspirin Exacerbated Respiratory Disease (AERD...
Detailed Description
This is a prospective trial of approximately 60 subjects with AERD to explore the mechanisms behind the physiologic reactions that occur when drinking alcoholic beverages. At various time points patie...
Eligibility Criteria
Inclusion
- Healthy Controls - must be 21 years or older
- Aspirin Tolerant Asthma and AERD arms must note a sensitivity to alcoholic beverages
Exclusion
- Enzymopathies
- Mastocytosis
- Alcoholism
- Prior severe respiratory reaction to alcohol consumption
- Current pregnancy
- Monoamine Oxidase Inhibitor (MAOI) use
- Age under 21
- Use of leukotriene modifier 1 week before study intervention
- Having undergone and maintained aspirin desensitization
Key Trial Info
Start Date :
May 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2018
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT03441438
Start Date
May 1 2018
End Date
September 1 2018
Last Update
May 7 2018
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Virginia
Charlottesville, Virginia, United States, 22908