Status:
UNKNOWN
Cognitive Outcomes and Neuroimages Associated With Anesthesia-Related EEG Signatures
Lead Sponsor:
Massachusetts General Hospital
Conditions:
Elderly
General Anesthesia
Eligibility:
All Genders
65+ years
Brief Summary
In this study, we propose to evaluate the relationship between the alpha oscillation dynamics and the signals derived from the brain images related to brain aging.
Detailed Description
In 1955 Bedford reported the "adverse cerebral effects of anesthesia on old people" and suggested precautions in relation to operations on the elderly. Since then, many studies have investigated the i...
Eligibility Criteria
Inclusion
- 65 years old or above (male and female)
- American Society of Anesthesiologists (ASA) physical status classification of I, II or III.
- Candidates scheduled for open or laparoscopic general surgical procedures under general anesthesia
- No cognitive impairment base on Telephone Interview for Cognitive Status (TICS)
- Fluency in English Language
Exclusion
- Prior diagnosis of dementia
- Prior diagnosis of Alzheimer's Disease
- Prior history of psychiatric or neurological diseases including:
- Schizophrenia
- Parkinsonism
- Epilepsy or seizure
- Brain injury
- Brain tumors/metastases
- Encephalitis
- Stroke, CVA, TIA
- Drug or alcohol abuse:
- Any history of IV drug abuse
- Alcohol/drug (non-IV) abuse \<10 years
- Language impairment
- Hearing or visual impairment
- Severe obesity (BMI ≥40 kg/m2)
- MRI contraindications, such as presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments, or foreign objects in the eyes, skin, or body
- Body weight of \> 300 lbs. (weight limit of the MRI table)
Key Trial Info
Start Date :
February 13 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 11 2024
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT03442179
Start Date
February 13 2019
End Date
May 11 2024
Last Update
August 1 2023
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114