Status:
UNKNOWN
CPAP for OSA on Myocardial Salvage After pPCI for STEMI Patients
Lead Sponsor:
Beijing Anzhen Hospital
Conditions:
Obstructive Sleep Apnea
ST Elevation Myocardial Infarction
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
The aim of this randomized controlled trial to investigate the effects of CPAP treatment on myocardial salvage index and clinical outcomes at 3 months in patients with OSA and ST-Segment Elevation Myo...
Eligibility Criteria
Inclusion
- 18 to 80 years old
- First-time STEMI
- Successful PPCI (≥1 coronary artery) within 24h after symptom onset
- Moderate to severe OSA (AHI≥15)
- Written informed consent
Exclusion
- Prior myocardial infarction
- Prior myocardial revascularization (PCI or CABG)
- Cardiogenic shock (mean arterial pressure \<60mmHg), severe heart failure (Killip≥3)
- LM or multivessel disease indicated for CABG
- History of stroke
- Severe insomnia, chronic sleep deprivation, abnormal circadian rhythm (sleep \<4h/night)
- Severe COPD: FEV1/FVC \<70% or FEV1 \<50% predicted value (within 4 weeks)
- Predominantly central sleep apnea (≥25% central events or central AHI ≥10/h)
- Previous or current use of CPAP
- Severe comorbidities: eg. malignancy (life expectancy \<2 years)
- Known or planned pregnancy
- Known contraindication to CMR
- Patients with contraindication to CPAP or who cannot tolerate it
- Participation in other clinical trial in recent 3 months
- Any condition that in the opinion of investigator that may jeopardize patient compliance, eg. significant memory, perceptual, or behavioral disorder, depression, severe alcohol consumption, or a history of noncompliance
Key Trial Info
Start Date :
March 26 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2019
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT03444857
Start Date
March 26 2018
End Date
June 30 2019
Last Update
February 23 2018
Active Locations (2)
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1
Beijing Hospital
Beijing, Beijing Municipality, China, 100000
2
Beijing Anzhen Hospital, Capital Medical University
Beijing, China, 100029