Status:
UNKNOWN
Extracorporeal Low-intensity Shockwave in Diabetic Nephropathy
Lead Sponsor:
Chang Gung Memorial Hospital
Conditions:
Diabetic Nephropathy Type 2
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
In the current study, we use extracorporeal low-intensity shockwave therapy (ESWT) to treat on patients with type 2 diabetes in stage 3-4 chronic kidney disease and see whether it can improve the prot...
Detailed Description
Diabetic nephropathy is the major contributor to end stage renal disease worldwide. Extracorporeal shock wave treatments (ESWT) with low-intensity was reported to be beneficial in inducing cell regene...
Eligibility Criteria
Inclusion
- Age \>18 y/o or \<80 y/o
- Diagnosed as type 2 diabetes.
- Baseline HbA1C \<7.5%
- Baseline glomerular filtration rate (eGFR) ≧15 and \<60 ml/min/1.73m2
- Baseline urine albumin-to-creatinine ratio (UACR) \>30 and \<3000 mg/g
- Subject receives ACEi or ARB for 3 months before enrollment
- Subject is willing to sign the permit and receive 12 times shockwave therapy
Exclusion
- Subject is pregnant or breast feeding
- Subject has cancer or chronic inflammatory disease
- Subject has bleeding tendency, eg thrombocytopenia, PT INR \> 2.5
- Subject has active urinary tract infection or other active infections
- Subject's sBP\>160mmHg or dBP\>100mmHg
- Subject has stroke, cardiac infection or arrhythmia in 6 months before enrollment
- Subject has local inflammation or infection over treatment areas
- Subject has pacemaker or other metal implants.
Key Trial Info
Start Date :
July 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2020
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT03445247
Start Date
July 1 2017
End Date
June 30 2020
Last Update
February 26 2018
Active Locations (1)
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1
Kaohsiung Chang-Gung Memorial Hospital
Kaohsiung City, Please Select, Taiwan, 833