Status:
COMPLETED
Offset Analgesia as a Measure of Central Sensitization in Children
Lead Sponsor:
Boston Children's Hospital
Conditions:
Chronic Pain Syndrome
Chronic Daily Headache
Eligibility:
All Genders
10-17 years
Phase:
NA
Brief Summary
Pediatric chronic pain disorders are common and consequential in Western societies, occurring in 25-80% of population-based samples with a median prevalence of 11-38% and significant pain-related disa...
Detailed Description
Specific Aims/Objectives To date, OA has not been evaluated in pediatric chronic pain disorders. In the current study, the investigators plan to measure OA responses in a population of common pediatri...
Eligibility Criteria
Inclusion
- Patients experiencing chronic pain defined as pain persisting for 3 months.
- Ages 10-17 years, both sexes and all races and ethnic groups.
- Patients with moderate pain rated as 5/10 and greater on a numeric rating scale of 0 to 10 points.
- English speaking.
- If patients are taking medications such as psychotropic (e.g., SSRI), opioid, anxiolytics or anticonvulsive drugs for pain such as gabapentinoids, they must be on stable doses for at least one week.
- Stable anxiety and depression.
Exclusion
- Intermittent pain or pain of less than 3-month duration.
- Allodynia in the upper extremities
- Patients with poor understanding of English language or developmental disorders that affect the ability to reliably rate pain, read questionnaires and follow study instructions.
- Children and adolescents with a history of central nervous system, heart, kidney, liver, and respiratory system diseases.
- Psychiatric disorders such as conversion, bipolar disorder or psychosis.
Key Trial Info
Start Date :
April 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2020
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT03445403
Start Date
April 1 2018
End Date
December 1 2020
Last Update
February 21 2021
Active Locations (1)
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1
Boston Children's Hospital
Waltham, Massachusetts, United States, 02453