Status:
TERMINATED
MRI to Assess Fibrosis in Eosinophilic Esophagitis Patients
Lead Sponsor:
Mayo Clinic
Conditions:
Eosinophilic Esophagitis
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
Can an MRI detect and monitor the inflammatory and fibrotic possess in patients with Eosinophilic Esophagitis
Detailed Description
MRI will be performed on a 1.5T magnet. Patients will be scanned in an oblique prone position similar to how esophageal distention is assessed at barium fluoroscopy. The following sequences and ration...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Adults ages 18-70 years of age
- Diagnosis of EoE, i.e. symptoms of esophageal dysfunction with histologic finding of 15 or more eosinophils per high power field on esophageal biopsy despite 8 weeks of high dose proton pump inhibitor therapy.
- All Subjects diagnosed with Eosinophilic Esophagitis pre and pose therapy
- Exclusion criteria:
- Clinical evidence of infectious process potentially contributing to dysphagia (e.g. candidiasis, CMV, herpes)
- Other cause of dysphagia identified at endoscopy or esophagram (e.g. reflux esophagitis, stricture, web, ring, achalasia, esophageal neoplasm)
- Esophageal minimal diameter \< 13 mm on structured barium esophagram
- Inability to read due to: Blindness, cognitive dysfunction, or English language illiteracy
- Pregnant women
- Presence of body metallic fragments or devices that prohibit use of MRI
- History of renal disease
- eGRF \<30
Exclusion
Key Trial Info
Start Date :
March 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 15 2019
Estimated Enrollment :
8 Patients enrolled
Trial Details
Trial ID
NCT03446118
Start Date
March 1 2017
End Date
April 15 2019
Last Update
February 28 2022
Active Locations (1)
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1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905