Status:
ACTIVE_NOT_RECRUITING
Vasopressin and Pain Perception in the Brain
Lead Sponsor:
University of Maryland, Baltimore
Conditions:
Acute Pain
Eligibility:
All Genders
18-65 years
Phase:
PHASE1
PHASE2
Brief Summary
The feeling of pain is not just a sensory experience, but is also influenced by emotions, beliefs and expectations, making pain a highly subjective experience. This is evident in clinical practice, wh...
Detailed Description
The purpose of this research is to investigate how vasopressin (AVP) influences the neural mechanisms associated with observationally-induced analgesia. More specifically, the investigators will deter...
Eligibility Criteria
Inclusion
- Age ( 18-55 years old)
- English speaker (written and spoken)
Exclusion
- Cardiovascular, neurological diseases, pulmonary abnormalities, kidney disease, liver disease, degenerative neuromuscular disease, history of cancer within past 3 years
- Any history of chronic pain disorder or currently in pain
- Severe psychiatric condition (e.g. schizophrenia, bipolar disorders, mania, autism) and /or psychiatric condition leading to treatment and/or hospitalization within the last 3 years.
- Family (first degree) history of mania, schizophrenia, or other psychoses
- Lifetime alcohol/drug dependence or alcohol/drug abuse in past 3 months
- Pregnancy or breast feeding
- Color-blindness
- Impaired, uncorrected hearing
- History of angioedema
- High blood pressure (above 140 mmHg) or symptomatic low blood pressure
- History of fainting
- Left handed
- Allergies or sensitivities to creams, lotions or food coloring
- Any non-organic implant or any non-removable metal device (e.g. pacemaker, cochlear implants, stents, surgical clips, non-removable piercings)
- Any prior eye injury or the potential of a foreign body in the eye (e.g. worked in metal fields)Persisting functional impairment due to a head trauma
- Fear of closed spaces
- Any other contraindications for MRI (e.g. large tattoos on head and neck)
- Previously participated in a "Pain Perception in the Brain" Study
- Failed drug test (testing for opiates, cocaine, methamphetamines, amphetamines and THC)
Key Trial Info
Start Date :
September 17 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2026
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT03446456
Start Date
September 17 2018
End Date
December 31 2026
Last Update
May 20 2025
Active Locations (1)
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1
Luana Colloca
Baltimore, Maryland, United States, 21201-1512