Status:
COMPLETED
Determining the Muscle Anabolic Properties of Phosphatidic Acid.
Lead Sponsor:
University of Birmingham
Collaborating Sponsors:
University of Nottingham
Conditions:
Sarcopenia
Eligibility:
MALE
65-80 years
Phase:
NA
Brief Summary
Ageing is characterized by a loss of muscle mass that is detrimental for physical function and metabolic health and increases the risk of mortality. The loss of muscle protein mass with ageing is char...
Detailed Description
The investigators will recruit 16 healthy (non-obese, non-diabetic, non-smokers) elderly men aged 65-80 yrs to complete a double-blinded, parallel designed study, in which they will be randomly assign...
Eligibility Criteria
Inclusion
- Be a non-smoking male between 65 and 80 years.
- Have a BMI between 18 and 25 kg/m2.
- Be in good general health: no cardiovascular or metabolic diseases.
Exclusion
- Health problems such as: heart disease, rheumatoid arthritis, uncontrolled hypertension, poor lung function, or any health condition that might put you at risk when participating in this study.
- Generalised neuromuscular disease (such as Parkinson's disease or motorneurone disease).
- Failure to obtain clearance for exercise participation from your GP or negative advice given by your GP concerning exercise participation.
- Involvement in regular structured resistance exercise training at the time of the study.
- Consumption of any analgesic drugs, anti-inflammatory drugs, or medication that is known to affect protein metabolism (beta-blockers, corticosteroids, NSAIDs).
- Participants who have undergone muscle biopsy testing or isotope infusion procedures within the last 5 years.
Key Trial Info
Start Date :
August 1 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2017
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT03446924
Start Date
August 1 2015
End Date
September 1 2017
Last Update
February 27 2018
Active Locations (1)
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1
University of Birmingham, School of Sport, Exercise and Rehabilitation Sciences
Edgbaston, West Midlands, United Kingdom, B15 2TT