Status:
COMPLETED
Retinal Nerve Fiber Layer Thickness and Cerebrospinal Fluid Aβ/Tau
Lead Sponsor:
Shanghai 10th People's Hospital
Collaborating Sponsors:
Massachusetts General Hospital
Conditions:
Alzheimer Disease
Eligibility:
All Genders
50+ years
Brief Summary
To test the hypothesis that retinal nerve fiber layer (RNFL) thickness is correlated with Aβ and Tau concentration of cerebrospinal fluid (CSF) in an older population.
Detailed Description
retinal nerve fiber layer (RNFL) thickness changing has been reported in Alzheimer's Disease (AD) patients at an early stage, and has been demonstrated as a potential biomarker able to predict cogniti...
Eligibility Criteria
Inclusion
- 50 years old or older;
- five years or more of education and scores of MMSE ≥ 24 points;
- Chinese as their first language;
- Having spinal anesthesia.
Exclusion
- prior diagnoses of neurologic diseases, e.g., dementia, Parkinson's diseases, multiple sclerosis or stroke according to DSM-IV;
- history of mental disorders (e.g., major depressive disorder and schizophrenia) diagnosed according to DSM-IV;
- known diseases contributing to the retina pathologies, e.g., diabetes, glaucoma or increased intraocular pressure (more than 22 mmHg), cataract, and macular degeneration and hypermyopia;
- unwillingness to comply with the cognitive assessments;
- ungradable images of OCT.
Key Trial Info
Start Date :
August 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2014
Estimated Enrollment :
86 Patients enrolled
Trial Details
Trial ID
NCT03447613
Start Date
August 1 2013
End Date
December 31 2014
Last Update
November 30 2018
Active Locations (1)
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1
Shanghai 10th People's Hospital
Shanghai, Shanghai Municipality, China, 200072