Status:
COMPLETED
The Effects of Resveratrol Supplementation on Cognition, Cerebral Blood Flow, Microbiota and Systemic Inflammation.
Lead Sponsor:
Northumbria University
Collaborating Sponsors:
Evolva SA
Conditions:
Cognitive Function and Mood
Cerebral Blood Flow
Eligibility:
All Genders
35-60 years
Phase:
NA
Brief Summary
Previous research shows that a diet high in fat has harmful effects on gut health. This increases the chance of developing obesity-related diseases (such as type 2 diabetes) and disrupts cognition and...
Detailed Description
Each participant will be required to attend the laboratory on four occasions. The first of these will be an initial screening/training visit, this will take place in the afternoon and last 3 hours in ...
Eligibility Criteria
Inclusion
- Interested in taking part in the study
- Healthy
- Aged 35-60 years (inclusive)
- Have a BMI of between 25-39.9
- Willing to consume your normal diet during the 12 week supplementation period
Exclusion
- You should not take part if you:
- Are aged under 35 or over 60
- Have a Body Mass Index (BMI) lower than 25 or higher than 39.9.
- Have taken antibiotics (including pre- and pro-biotic supplements/drinks) during the previous 8 weeks
- Have irregular bowel movements (less than 1 per day)
- Have any pre-existing medical conditions/illness with some exceptions - please check with the researcher
- Have type 1 or type 2 diabetes
- Are currently taking prescription medications with some exceptions- please check with the researcher
- Have a visual impairment that cannot be corrected by glasses or contact lenses, including colour blindness.
- English is not your first language or your English proficiency is not equivalent to the International English language test system (IELTS) band 6 or above
- Have any learning difficulties or dyslexia
- Currently suffer from frequent migraines that require medication (\>1 per month)
- Have any food allergies, intolerances or sensitivities
- Have high blood pressure (systolic over 159 mm Hg or diastolic over 99 mm Hg)
- Smoke
- Have a history of alcohol or drug abuse
- Are pregnant, seeking to become pregnant or lactating
- Are unable to complete all of the study assessments
- Are currently participating in any other clinical or nutritional intervention study, or have done within the past 4 weeks
- Have any health condition that would prevent fulfilment of the study requirements
- Have habitually used supplements within the last month (defined as more than 3 consecutive days or 4 days in total)
- Have an excessive caffeine intake (\>500mg per day) - equivalent to 5/6 cups of coffee/8 cups of tea per day or equivalent from other sources
- Consume more than 5 portions of fruit or vegetables per day
- Any sleep disturbances or take sleep aid medication
- Have any known active infections
- You have or may think you are at risk of having syphilis, hepatitis, the Human T - lymphotropic virus or the Human Immunodeficiency Virus?
- You have ever had breast cancer and/or a mastectomy
- You have haemophilia or any similar clotting disorder
- Do not have a bank account (required for payment)
Key Trial Info
Start Date :
February 6 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 13 2019
Estimated Enrollment :
110 Patients enrolled
Trial Details
Trial ID
NCT03448094
Start Date
February 6 2018
End Date
July 13 2019
Last Update
March 17 2020
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Northumbria University
Newcastle upon Tyne, Tyne and Wear, United Kingdom, NE1 8ST