Status:
COMPLETED
Improving Metabolic Health in Patients With Diastolic Dysfunction
Lead Sponsor:
University of Texas Southwestern Medical Center
Conditions:
Obesity
Heart Failure, Diastolic
Eligibility:
All Genders
40-60 years
Phase:
NA
Brief Summary
The purpose of this study is to determine whether 1 year of supervised exercise training in obese individuals at high risk for developing HF, incorporating high intensity interval training (HIIT) two ...
Detailed Description
The global objective of this project is to test novel strategies to prevent obesity related abnormalities in diastolic function that may progress to heart failure with preserved ejection fraction (HFp...
Eligibility Criteria
Inclusion
- ejection fraction \>0.50
- \>2.0 kg visceral fat (intra- and retro-peritoneal adipose tissue)
- either a high sensitivity troponin (\>0.6pg/ml), or NTBNP (\>40 ng/ml)
- age range 40 -60
- BMI range 30 - 50 kg/m2
Exclusion
- age \< 40 or \> 60
- body mass index \> 50, \< 30 kg/m2
- history of insulin dependent diabetes, heart failure, myocarditis, restrictive cardiomyopathy, permanent/persistent atrial fibrillation, severe chronic obstructive pulmonary disease, unstable coronary artery disease or recent (\<12 month) acute coronary syndrome, cerebrovascular disease as evidenced by prior transient ischemic attack or stroke and active/recent tobacco use (quit \< 5 years).
- Female patients will be excluded if they are pregnant or plan to become pregnant (expected rare occurrence in the selected age range of 40 - 60). 5. Patients will be excluded if they are taking non-statin lipid lowering agents (fibrates, niacin, or fish oils)
- Contra-indications to MRI
Key Trial Info
Start Date :
June 1 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2019
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT03448185
Start Date
June 1 2015
End Date
July 1 2019
Last Update
January 5 2023
Active Locations (1)
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1
The Institute for Exercise and Environmental Medicine
Dallas, Texas, United States, 75231