Status:
COMPLETED
Effect of Kale Consumption on Human Xenobiotic Metabolizing Enzymes
Lead Sponsor:
USDA Beltsville Human Nutrition Research Center
Conditions:
Healthy Volunteers
Eligibility:
All Genders
21-75 years
Phase:
NA
Brief Summary
The primary objective of this study is to determine how daily consumption of kale changes the activity of human xenobiotic metabolizing enzymes. Secondary objectives are to measure absorption and meta...
Detailed Description
Consumption of Brassica vegetables (which include broccoli, cabbage, and kale) is inversely associated with the incidence of several cancers, including cancers of the lung, stomach, liver, colon, rect...
Eligibility Criteria
Inclusion
- 5 years cancer free
- Not a tobacco product user
- Blood glucose less than 126 mg/dL
- Able to voluntarily agree to participate and sign an informed consent document
Exclusion
- Brassica vegetable allergy or intolerance
- use of oral contraceptives
- Women who have given birth in the previous 12 months
- Type 2 diabetes requiring the use of diabetes pills, insulin, or non-insulin shots
- Use of blood-thinning medications such as Coumadin (warfarin), Dicumarol, or Miradon (anisindione)
- History of bariatric surgery or nutrient malabsorption disease
- Pregnant, lactating, or intending to become pregnant during the study period
- Crohn's disease or diverticulitis
- Suspected or known strictures, fistulas or physiological/mechanical GI obstruction
- Self-report of alcohol or substance abuse within the past 12 months and/or current acute treatment or rehabilitation program for these problems (long-term participation in Alcoholics Anonymous is not an exclusion)
Key Trial Info
Start Date :
April 18 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2018
Estimated Enrollment :
27 Patients enrolled
Trial Details
Trial ID
NCT03449849
Start Date
April 18 2018
End Date
August 1 2018
Last Update
September 12 2018
Active Locations (1)
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1
USDA-ARS Beltsville Human Nutrition Research Center
Beltsville, Maryland, United States, 20705