Status:
TERMINATED
Arm Exercise Versus Pharmacologic Stress Testing for Clinical Outcome
Lead Sponsor:
VA Office of Research and Development
Collaborating Sponsors:
VA St. Louis Health Care System
Conditions:
Veterans Referred to the St. Louis VAMC Stress Tes
Eligibility:
All Genders
21-100 years
Brief Summary
This is a 5-year clinical trial to evaluate whether arm exercise electrocardiographic (ECG) stress testing without or with coronary artery calcium scoring (-/+ CAC) is non-inferior to treadmill ECG st...
Detailed Description
Note: Recruitment is temporarily suspended because of VA-ORD moratorium due to Covid-19 pandemic. 04/01/2020 Treadmill exercise capacity and other physiologic responses to leg exercise are powerful p...
Eligibility Criteria
Inclusion
- Any veteran referred to the St. Louis VA Healthcare System stress testing laboratory for a cardiac stress test
Exclusion
- Contra-indications to stress testing such as acute coronary syndrome, uncompensated heart failure, or unstable cardiac dysrhythmias Inability to perform arm exercise stress testing
- Contra-indications to regadenoson stress testing such as significant reversible airway disease, heart block, or low blood pressure
- An abnormal baseline ECG (e.g. left bundle branch block, widespread ST segment depression of at least 1 mm, ventricular paced rhythm) that precludes interpretation of the stress ECG
- Contra-indications to cardiac computed tomographic angiography (CTA) such as contrast allergies and renal dysfunction (glomerular filtration rate \< 30 ml/min)
Key Trial Info
Start Date :
July 1 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 5 2021
Estimated Enrollment :
133 Patients enrolled
Trial Details
Trial ID
NCT03449888
Start Date
July 1 2018
End Date
February 5 2021
Last Update
February 17 2022
Active Locations (1)
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1
St. Louis VA Medical Center John Cochran Division, St. Louis, MO
St Louis, Missouri, United States, 63106