Status:
COMPLETED
Personalized Surveillance Protocol for Serrated Polyposis Syndrome
Lead Sponsor:
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Conditions:
Serrated Polyposis Syndrome
Colorectal Cancer
Eligibility:
All Genders
18+ years
Brief Summary
Serrated polyposis syndrome (SPS) is a condition characterized by the presence of multiple serrated polyps (SPs) spread throughout the colorectum and is associated with an increased risk of colorectal...
Detailed Description
This study has an international multi-centre prospective cohort design. The study will be directed by the Academic Medical Centre (AMC), Amsterdam, the Netherlands. Population base All patients treat...
Eligibility Criteria
Inclusion
- Patients with SPS WHO 1 criterion (cumulative ≥ 5 histologically diagnosed SPs proximal to the sigmoid colon, of which 2 ≥ 10mm in diameter) and/or WHO 3 criterion (cumulative ≥ 20 SPs spread throughout the colon, at least 3 of the SPs will have to be situated proximal to the sigmoid colon).
- Age 18 years or older
Exclusion
- \- Germline mutation for hereditary colorectal cancer syndrome (e.g. familial adenomatous polyposis, Lynch syndrome. Not including heterozygous MUTYH mutation)
- Inflammatory bowel disease
- Proctocolectomy
- History of radiotherapy in abdominal region
Key Trial Info
Start Date :
January 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 13 2018
Estimated Enrollment :
319 Patients enrolled
Trial Details
Trial ID
NCT03450889
Start Date
January 1 2013
End Date
April 13 2018
Last Update
April 3 2019
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