Status:
UNKNOWN
N-Acetyl Cysteine Protects Pulpal Stem Cells in Endodontic Revascularization
Lead Sponsor:
University of California, Los Angeles
Conditions:
Endodontic Disease
Eligibility:
All Genders
6-18 years
Phase:
EARLY_PHASE1
Brief Summary
Pulp re-vascularization/regeneration is a procedure performed to allow pulpal stem cells to survive and/or differentiate to allow immature tooth root structures to grow to full maturity. Currently, th...
Detailed Description
We will recruit 14-18 patients under the age of 18 by means of advertising at UCLA. Two groups will be formed, one with NAC treatment during endodontic revascularization and one without. Each patient ...
Eligibility Criteria
Inclusion
- Inclusion criteria include the following:
- Subjects will be self and parent-reported as healthy individuals with no significant medical issues.
- Radiographic assessment will determine that root(s) have not grown to completion
- 2\) Vitality tests (cold testing with Endo ice and Electric pulp testing) will determine the tooth to be necrotic 3) Palpation and percussion tests may or may not be positive 4) Probings will be within 1-5mm 5) Patient will commit to coming to 2-3 treatment appointments lasting 1-3 hours each. Thereafter, patient will commit to come for followup recall appointments 6 and 12 months following last treatment appointment.
- 6\) Patient must be able to tolerate sitting in a dental chair for 1-3 hours. 7) Patient will be in the age range of 6 to 18 years
Exclusion
- Exclusion criteria include patients who cannot tolerate sitting in a dental chair due to anxiety for 1-2 hours.
Key Trial Info
Start Date :
June 15 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 15 2020
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT03451435
Start Date
June 15 2018
End Date
June 15 2020
Last Update
October 30 2019
Active Locations (1)
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1
University of California, Los Angeles Dept of Graduate Endodontics
Los Angeles, California, United States, 90095