Status:
COMPLETED
Effect of Locally-Applied Simvastatin on Clinical Attachment Level and Alveolar Bone in Periodontal Maintenance Patients
Lead Sponsor:
University of Nebraska
Conditions:
Periodontal Diseases
Eligibility:
All Genders
40-85 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to determine of local application of commericially-available, FDA-approved preparation of simvastatin is effective in increasing clinical attachment levels (primary outcom...
Detailed Description
Dental records of patients attending routine periodontal maintenance therapy visits at the UNMC College of Dentistry clinics are reviewed as part of the direct supervision by faculty, including invest...
Eligibility Criteria
Inclusion
- age 40-85 years,
- diagnosis of chronic advanced adult periodontitis,
- one quadrant with at least one 6-9 mm interproximal pocket,
- overall good systemic health,
- willingness to sign consent form.
Exclusion
- systemic diseases which significantly impact periodontal inflammation and bone turnover (e.g. rheumatoid arthritis),
- taking drugs which significantly impact periodontal inflammation and bone turnover (e.g. chronic use of steroids or non-steroidal anti-inflammatory drug (\>325 mg/d), estrogens, bisphosphonates, calcitonin, methotrexate),
- surgical periodontal therapy within the past year,
- pregnant or breast-feeding females.
Key Trial Info
Start Date :
March 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2020
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT03452891
Start Date
March 1 2019
End Date
December 31 2020
Last Update
October 5 2023
Active Locations (1)
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1
University of Nebraska, College of Dentistry
Lincoln, Nebraska, United States, 68583