Status:
COMPLETED
Impact of Reducing Antihypertensive Treatment on Mortality in Frail Subjects With Low Systolic Blood Pressure (SBP).
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Hypertension
Eligibility:
All Genders
80+ years
Phase:
NA
Brief Summary
The investigators hypothesize that a gradual reduction in antihypertensive treatment in medical-social institutions patients with low systolic blood pressure (SBP) can improve survival through a contr...
Detailed Description
High blood pressure (BP), principally systolic hypertension, is a common condition in older people and is considered a major determinant not only of cardiovascular morbidity and mortality, but also of...
Eligibility Criteria
Inclusion
- Male and female patients aged 80 and over
- Patients living in nursing homes
- Patients with a SBP \< 130 mmHg measured in Medical-Social Institutions using the connected blood pressure monitor supplied for the study (average of the last 2 out of 3 measurements after 10 min rest)
- Hypertensive patients whose treatment contains at least 2 antihypertensive molecules and whose treatment has been stabilised for at least :
- 3 weeks in the case of the introduction or discontinuation of an anti-HBP drug
- 2 weeks in the case of a change in the dosage of one of the anti-HBP drugs.
- Patients affiliated to a social security scheme
- Patients who have signed the informed consent form (failing which, the legal representative)
- Patients with dementia or with a severe reduction in physical function (impaired vision, asthenia, advanced osteoarthritis, severe tremors, etc.) and/or cognitive function may be included in this study with the agreement of their carers or family/relatives.
Exclusion
- Patients in whom no antihypertensive molecule can be reduced for specific reasons (heart failure with ejection fraction \<40%, fluid retention due to heart failure, coronary artery disease and diabetic nephropathy).
- Patients with an estimated life expectancy of \<3 months
- Patients who have already been included in this study or in another study at the same time
Key Trial Info
Start Date :
October 2 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 15 2024
Estimated Enrollment :
1048 Patients enrolled
Trial Details
Trial ID
NCT03453268
Start Date
October 2 2018
End Date
August 15 2024
Last Update
July 20 2025
Active Locations (124)
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1
CHU Angoulême (Expert center)
Angoulême, France, 16000
2
Font Douce (Nursing Home)
Angoulême, France, 16000
3
Keriolet (Nursing Home)
Auray, France, 56400
4
Kerleano (Nursing Home)
Auray, France, 56400