Status:
COMPLETED
Effect of Photodynamic Therapy on Gingival Crevicular Cytokines in Periodontitis Patients
Lead Sponsor:
National University of Singapore
Conditions:
Periodontitis, Adult
Periodontal Pocket
Eligibility:
All Genders
21+ years
Phase:
NA
Brief Summary
Systemically healthy periodontitis patients were recruited in this single-blind, split-mouth, randomized controlled clinical trial. After SRP, PDT was applied at probing depth (PD) ≥ 4 mm at test quad...
Detailed Description
Periodontal parameters and cytokine IL-1β, IL-6, IL-8, TNF-α, MMP-8 levels were analysed.
Eligibility Criteria
Inclusion
- Adults who were medically fit or have medical condition that did not alter the outcome of periodontal treatment.
- Females who were not pregnant or nursing.
- Controlled diabetes mellitus with HbA1c \< 7.5 mmol/L.
- Not on any antibiotics or steroids 3 months prior to periodontal treatment.
- Diagnosed to have either localized or generalized chronic or aggressive periodontitis (Armitage, 1999) with all 4 quadrants having at least 2 sites with probing depth ≥ 4 mm.
- Consented to follow the non-surgical periodontal treatment (scaling and root planing) with PDT throughout the period of study, i.e. approximately 6 months.
Exclusion
- Allergic to photosensitizer or dye
- Pregnant lady and nursing mothers
- Uncontrolled diabetes
Key Trial Info
Start Date :
January 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 30 2013
Estimated Enrollment :
51 Patients enrolled
Trial Details
Trial ID
NCT03453476
Start Date
January 1 2012
End Date
June 30 2013
Last Update
March 5 2018
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