Status:
COMPLETED
Effects of Polyphenols on Iron Absorption in Iron Overload Disorders.
Lead Sponsor:
University Hospital, Clermont-Ferrand
Conditions:
Dysmetabolic Iron Overload Syndrome
Genetic Hemochromatosis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Dysmetabolic iron overload syndrome and genetic hemochromatosis are frequent causes of iron overload. Polyphenols are efficient iron-chelators. Investigator hypothesize that polyphenol supplementation...
Detailed Description
Iron overload diseases are highly prevalent. Dysmetabolic iron overload syndrome involves 15% of men with metabolic syndrome X. Genetic hemochromatosis is the most common genetic disease in Northern E...
Eligibility Criteria
Inclusion
- 18 years old and over
- Written consent.
- For DIOS Group : at least one criteria of the metabolic syndrome as defined by the International Diabetes Federation, associated with hepatic iron overload measured by MRI (at least 50 µmol/g) or by hepatic biopsy.
- For Genetic Haemochromatosis type 1 Group: homozygosity mutation C282Y in HFE gene ; patients undergoing therapeutic phlebotomies.
Exclusion
- Persons under guardianship
- Body-weight less than 45 kg
- Hemoglobin less than 9 g/dL.
- Intestinal malabsorption of any cause
- Current use or previous use during the last 2 months of iron supplement.
- Current use or previous use during the last 2 months of treatment interacting with iron absorption (increasing like C vitamin or decreasing like iron chelators)
- Other causes of hyperferritinemia : chronic inflammatory syndrome, porphyria, hyperferritinemia-cataract-syndrome, chronic alcohol consumption, chronic hemolysis.
Key Trial Info
Start Date :
April 9 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 20 2018
Estimated Enrollment :
41 Patients enrolled
Trial Details
Trial ID
NCT03453918
Start Date
April 9 2018
End Date
July 20 2018
Last Update
April 1 2019
Active Locations (1)
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1
CHU Clermont-Ferrand
Clermont-Ferrand, France, 63003