Status:
COMPLETED
Cerebellar rTMS to Improve Gait Recovery
Lead Sponsor:
I.R.C.C.S. Fondazione Santa Lucia
Conditions:
Stroke
Gait, Hemiplegic
Eligibility:
All Genders
30-80 years
Phase:
NA
Brief Summary
The cerebellum is known to be strongly implicated in the functional reorganization of motor networks in stroke patients, especially for gait an balance functions. Repetitive transcranial magnetic stim...
Eligibility Criteria
Inclusion
- First ever-chronic ischemic stroke, i.e. at least 6 months after the stroke event,
- Left or right subcortical or cortical lesion of the middle cerebral artery with medium-severity stroke NHISS \<15 (All lesions must be documented by magnetic resonance imaging (T1- and T2-weighted images; 1.5T, GE scanners)
- No contraindication to brain MRI
- MEP recordable in order to evaluate the resting motor threshold (RMT)
Exclusion
- Epilepsy
- Severe general impairment or concomitant diseases (tumors, etc.)
- Age\> 80 years
- Infections in progress
- Patients with neurological diseases beyond stroke or with neuropsychiatric disorders or with neuropsychological disorders that could potentially compromise informed consent or compliance during the study.
- Treatment with benzodiazepines, baclofen, antidepressants, clonidine, beta blockers and other potentially interfering drug treatments on plasticity phenomena.
Key Trial Info
Start Date :
March 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2017
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT03456362
Start Date
March 1 2014
End Date
October 1 2017
Last Update
March 7 2018
Active Locations (1)
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1
Santa Lucia Foundation
Rome, Italy, 00179