Status:
COMPLETED
Acute Kidney Injury After Cardiac Surgery
Lead Sponsor:
University of Giessen
Collaborating Sponsors:
Guy's and St Thomas' NHS Foundation Trust
Shanghai Jiao Tong University School of Medicine
Conditions:
Acute Kidney Injury
Eligibility:
All Genders
18+ years
Brief Summary
The investigators seek to determine whether a reduced preoperative renal functional reserve predicts postoperative acute kidney injury in patients with normal estimated glomerular filtration rates und...
Detailed Description
Although acute kidney injury (AKI) frequently complicates cardiac surgery, methods to determine AKI risk in patients without underlying kidney disease are lacking. Renal functional reserve (RFR) can b...
Eligibility Criteria
Inclusion
- Subjects older than 18 years
- Subjects undergoing elective cardiac surgery (with or without cardiopulmonary bypass)
- Subjects with an estimated GFR ≥60 ml/min/1.73 m2 (CKD-Epidemiology Collaboration equation)
- Subjects who signed informed consent forms
Exclusion
- Preexisting acute kidney injury (as determined by all available serum creatinine values from hospital and outpatient medical records within the previous 90 days)
- Chronic kidney disease ≥ stage III (KDIGO)
- Subjects undergoing transcatheter aortic valve implantation (TAVI)
- Pregnancy
- Solitary kidney
- Diabetes mellitus type 1
- Recent cardiac arrest (within last 3 months)
- Liver failure or cirrhosis
- Total parenteral nutrition
- Hemoglobin \<11 g/dl
- Sepsis
- History of malabsorption, chronic inflammatory bowel disease, short bowel, or pancreatic insufficiency
- Transplant donor or recipient
- Active autoimmune disease with renal involvement
- Rhabdomyolysis
- Prostate hypertrophy with International Prostate Symptom Score ≥20
- Active neoplasm
- Decompensated heart failure / inability to pause angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers minimum 2 days before protein load
- Known iodine allergy (exclusion criteria only for those centres who use iohexol plasma clearance for determination of GFR)
- TSH \<0.3 µU/l (exclusion criteria only for those centres who use iohexol)
- Subjects who received intravenous radiocontrast agents within the 72 hours before the protein load
- Subjects who received NSAIDs within 48 hours before the protein load
Key Trial Info
Start Date :
March 1 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 21 2023
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT03457987
Start Date
March 1 2018
End Date
January 21 2023
Last Update
January 25 2023
Active Locations (1)
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1
University Clinic Giessen and Marburg - Campus Giessen
Giessen, Hesse, Germany, 35392