Status:
COMPLETED
Antibiotic Prophylaxis in Ragged Placental Membranes
Lead Sponsor:
Sarawak General Hospital
Collaborating Sponsors:
University Malaysia Sarawak
Conditions:
Endometritis Postpartum
Endometritis
Eligibility:
FEMALE
18+ years
Phase:
NA
Brief Summary
In some centres, women are routinely given a course of antibiotics postnatally if ragged placental membranes were present at delivery. The investigators examined the necessity such an intervention.
Detailed Description
Postpartum endometritis resulting in sepsis remain one of the leading cause of maternal mortality in developing countries. Ragged placental membrane is a risk factor for endometritis and is not infreq...
Eligibility Criteria
Inclusion
- All women who delivered vaginally beyond 24+0 weeks of gestation and were found to have ragged or retained placental membranes immediately after the third stage of labour were invited to participate in the study.
Exclusion
- Fever, within 5 days preceding delivery (Axillary temperature \> 37.5oC on 2 or more occasions at least 1 hour apart or temperature \> 38oC on one occasion). This also includes intrapartum fever.
- Required oral or intravenous antibiotics for any other obstetric-related (ex. third or fourth degree tears, preterm prelabour rupture of membranes) or non- obstetric related (ex. pneumonia, acute pyelonephritis) reasons
- Prolonged rupture of membrane (\>18 hours)
- Retroviral disease, on long term oral or parenteral steroid or receiving other forms of immunosuppressants, including chemotherapy within the last one year.
- Vaginal delivery for an intrauterine death
- Penicillin allergy
Key Trial Info
Start Date :
October 1 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2017
Estimated Enrollment :
716 Patients enrolled
Trial Details
Trial ID
NCT03459599
Start Date
October 1 2016
End Date
August 1 2017
Last Update
March 12 2018
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