Status:
TERMINATED
Sevoflurane in Chronic Obstructive Pulmonary Disease Exacerbation
Lead Sponsor:
University Hospital, Montpellier
Conditions:
COPD Exacerbation
Invasive Mechanical Ventilation
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Prospective, open-label, single-center, study to investigate the effect of sevoflurane sedation compared to a propofol-controlled arm during COPD exacerbation requiring invasive mechanical ventilation...
Eligibility Criteria
Inclusion
- Inclusion Criteria :
- COPD exacerbation
- Invasive mechanical ventilation and sedation for a planned duration of at least 24 hours
- Consent
- Age ≥ 18 years
- Affiliation or beneficiary of a social security scheme
- Exclusion Criteria :
- Contraindication to the administration of sevoflurane (personal or family history of malignant hyperthermia, allergy or halogenated anesthetic accident, chronic myopathy, halogenated toxic hepatitis, uncontrolled intracranial hypertension, unexplained leukocytosis after anesthesia with a halogenated agent)
- Contraindication to the administration of propofol (known hypersensitivity to propofol, soy, peanut or any of the excipients of the emulsion, antecedent of Propofol Related Infusion Syndrome)
- Refusal of consent
- Guardianship
- Age \< 18 years
- Pregnant or lactating woman
Exclusion
Key Trial Info
Start Date :
March 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 16 2020
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT03460015
Start Date
March 1 2018
End Date
December 16 2020
Last Update
December 28 2021
Active Locations (1)
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1
University hospital
Montpellier, Hérault, France, 34295