Status:
COMPLETED
Universal Endometrial Cancer DNA Sequencing for Detection of Lynch Syndrome and Personalized Care
Lead Sponsor:
Ohio State University Comprehensive Cancer Center
Conditions:
Endometrial Adenocarcinoma
Endometrial Carcinoma
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This clinical trial studies universal screening for deoxyribonucleic acid (DNA) mismatch repair deficiency in patients with endometrial cancer, mutations in the genes responsible for Lynch syndrome (i...
Detailed Description
PRIMARY OBJECTIVES: I. Molecular classification of tumor abnormalities through innovative upfront next-generation DNA sequencing. II. Identify endometrial cancer (EC) patients with inherited EC, spe...
Eligibility Criteria
Inclusion
- Adult women who had a hysterectomy or diagnostic biopsy proving endometrial adenocarcinoma (any stage) between 10/1/2017 and 4/30/2020, and received care at one of the participating hospitals
- Adult relatives of the EC patients found to have LS
Exclusion
- Individuals must be able to speak and read English; non-English speaking individuals will be excluded
- Individuals must be able to consent for themselves; those who are unable to consent for themselves for any reason will be excluded
- Prisoners will be specifically excluded from participation in the study
- Women who have uterine sarcomas are excluded
- Pregnant women are not eligible for the study
Key Trial Info
Start Date :
March 30 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 15 2025
Estimated Enrollment :
1001 Patients enrolled
Trial Details
Trial ID
NCT03460483
Start Date
March 30 2018
End Date
June 15 2025
Last Update
October 3 2025
Active Locations (9)
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1
Summa Akron City Hospital/Cooper Cancer Center
Akron, Ohio, United States, 44304
2
Aultman Health Foundation
Canton, Ohio, United States, 44710
3
University of Cincinnati
Cincinnati, Ohio, United States, 45219
4
TriHealth Cancer Institute-Westside
Cincinnati, Ohio, United States, 45245