Status:
COMPLETED
Effect of Magnesium Sulphate Infusion on Lung Mechanics and Oxygenation in COPD Patients Undergoing Total Laryngeal
Lead Sponsor:
Cairo University
Conditions:
Chronic Obstructive Pulmonary Diseases
Eligibility:
All Genders
40-80 years
Phase:
PHASE4
Brief Summary
Chronic Obstructive Pulmonary Disease \[COPD\] is a major cause of chronic morbidity and mortality worldwide. COPD is characterized by persistent progressive airflow limitation that adversely affects ...
Eligibility Criteria
Inclusion
- Patients undergoing cancer larynx surgery (partial laryngectomy, total laryngectomy with or without neck dissection).
- Age more than 40 years old
- ASA physical status II and III.
- Diagnosed as having COPD by preoperative spirometry. The classification is bases on the post-bronchodilators forced expiratory volume in the first second (FEV1). Mild COPD is diagnosed when FEV1 is \> 80% of predicted while moderate COPD is diagnosed when FEV1 is \< 80% and \> 50% of predicted and sever COPD is diagnosed when FEV1 is \< 50% and \> 30% of predicted
Exclusion
- o Patients with heart failure.
- History with arrhythmias or treatment with antiarrhythmic drugs.
- Patient with heart block or on beta blockers or calcium channel blockers.
- Patients with impaired renal function (creatinine \> 2)
- Patients with impaired liver function (ALT more than 2 folds).
- Patient with combined restrictive and obstructive pulmonary disease.
- Patients with preoperative tracheostomy.
- Patients with huge mass obstructing \> 50% of the view. (due to its influence on the spirometry measurements).
Key Trial Info
Start Date :
April 20 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 20 2019
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT03461328
Start Date
April 20 2018
End Date
March 20 2019
Last Update
August 21 2019
Active Locations (1)
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1
Anesthesia department - Faculty of medicine- Cairo University
Cairo, Egypt