Status:
COMPLETED
DNA Methylation and Hydroxymethylation Levels in Patients With Coronary Heart Disease
Lead Sponsor:
Chongqing Medical University
Conditions:
Coronary Heart Disease
Eligibility:
All Genders
65+ years
Brief Summary
The purpose of this trial is to investigate the relationship between DNA methylation and hydroxymethylation and the expression of DNMTs, TET family gene and the degree of coronary heart disease.
Detailed Description
1. To determine the levels of DNA methylation and hydroxymethylation with coronary heart disease. 2. To investigate the relationship between DNA methylation and hydroxymethylation and the degree of co...
Eligibility Criteria
Inclusion
- Male and Female. Patients older than 65 years old who are willing to participate in the study. CHD patients was defined as at least one lesion in a coronary artery or branches in coronary angiograms. Control group was defined as people with negative findings in coronary angiograms.
Exclusion
- Patients with concurrent infection or any documented inflammatory illness, such as arthritis or connective tissue diseases, or any other malignancy. Patients with a history of cardiomyopathy. Pregnant women. Severe hepatic dysfunction or End-stage renal failure. Uncontrolled hypertension.
Key Trial Info
Start Date :
January 1 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2018
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT03462277
Start Date
January 1 2018
End Date
October 1 2018
Last Update
July 17 2019
Active Locations (1)
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1
The First Affiliated Hospital of Chongqing Medical University
Chongqing, China