Status:
COMPLETED
Glucose-stimulated Gut Lipid Release
Lead Sponsor:
University Health Network, Toronto
Collaborating Sponsors:
Kensington Screening Clinic
Conditions:
Hyperlipidemias
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
During dietary fat absorption, the gut packages the majority of the fats into lipid particles that are secreted into blood circulation. The gut is also capable of storing a considerable amount of fats...
Detailed Description
Participants undergoing upper gastrointestinal endoscopy and duodenal biopsy for clinical indications are recruited after obtaining informed consent. They first have a high fat liquid formula. 5 to 9 ...
Eligibility Criteria
Inclusion
- Men and women, aged 18 to 60 years requiring endoscopy and duodenal biopsies for clinical indications, with no contraindications to the procedure, as judged by endoscopy doctor.
- Body mass index 20 to 27 kg/m2
Exclusion
- Patients with active inflammatory bowel disease
- Patients with Celiac disease, exocrine pancreatic insufficiency or small bowel malabsorption
- Patients with active bowel malignancy
- Patients with diabetes mellitus or known/ suspected motility disorders of the gut
- Patients with decompensated liver disease
- Patients on ezetimibe or bile acid sequestrants
- Unstable cardiac or respiratory disease
- Any changes to medication in the preceding month
Key Trial Info
Start Date :
October 16 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 11 2017
Estimated Enrollment :
46 Patients enrolled
Trial Details
Trial ID
NCT03464240
Start Date
October 16 2015
End Date
August 11 2017
Last Update
March 13 2018
Active Locations (2)
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1
Tornto General Hospital, UHN
Toronto, Ontario, Canada, M5G 1L7
2
Kensington Screening Clinic
Toronto, Ontario, Canada, M5T 3A9