Status:
COMPLETED
Streptokinase Versus Unfractionated Heparin Nebulization in Severe ARDS
Lead Sponsor:
Beni-Suef University
Conditions:
Acute Respiratory Distress Syndrome
Severe Acute Respiratory Syndrome
Eligibility:
All Genders
21-60 years
Phase:
PHASE3
Brief Summary
Background: Intra-alveolar clotting and alveolar collapse in ARDS is due to alveolar capillaries epithelial and leakage. Subsequently, collapse induces hypoxemia that is resistant to recruitment (RM)....
Detailed Description
Methods: The current study was carried out in the Intensive Care Unit of a tertiary University Hospital following approval by the local Research and Ethics Committee and after obtaining of a written ...
Eligibility Criteria
Inclusion
- Severe ARDS with PO2/FiO2 ratio\<100.
- Failure of Recruitment Maneuver (RM), Prone Position (PP) or Neuro-Muscular Block (NMB) to improve hypoxemia.
- No contraindications to thrombolytic or anticoagulant therapy (e.g. Coagulopathy, Heparin-Induced Thrombocytopenia, Previous administration of streptokinase, Known or suspected allergy to heparin or streptokinase, History of intracranial hemorrhage in the past 12 months, Patients with an epidural catheter in place or likely to be placed within the next 48 h.).
- Static compliance \<50 ml/cmH2O
Exclusion
- PO2/FiO2 ratio\>100.
- The success of Recruitment Maneuver (RM), Prone Position (PP) or Neuro-Muscular Block (NMB) to improve hypoxemia.
- Contraindications to thrombolytic or anticoagulant therapy (e.g. Coagulopathy, Heparin-Induced Thrombocytopenia, Previous administration of streptokinase, Known or suspected allergy to heparin or streptokinase, History of intracranial hemorrhage in the past 12 months, Patients with an epidural catheter in place or likely to be placed within the next 48 h.)
- Static compliance \>50 ml/cmH2O
Key Trial Info
Start Date :
February 18 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 30 2018
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT03465085
Start Date
February 18 2016
End Date
January 30 2018
Last Update
March 14 2018
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