Status:
COMPLETED
Effects of Liraglutide in Chronic Obstructive Pulmonary Disease
Lead Sponsor:
Claus Bogh Juhl
Conditions:
Pulmonary Disease, Chronic Obstructive
Eligibility:
All Genders
30-75 years
Phase:
PHASE4
Brief Summary
The study is a 44 weeks, prospective, randomized, placebo-controlled, double-blinded, parallel group two-center trial. Forty patients are recruited among the outpatients of the chronic obstructive pul...
Detailed Description
COPD is a common disease characterized by pulmonary inflammation, reduced pulmonary capacity, reduced physical activity and quality of life. Obesity is likewise a common disease characterized by infla...
Eligibility Criteria
Inclusion
- Informed consent obtained before any trial-related activities
- COPD as defined by FEV1/FVC\<70% after maximal broncho-dilatation and in accordance with the Gold guidelines 2017 (25)
- Previous smoking of ≥ 20 pack-years
- Overweight defined as BMI \> 27 kg/m2
- Age 30 - 75 years
- Women of childbearing potential must use a safe anti-contraceptive method
Exclusion
- Chronic treatment with systemic steroids (inhalation steroids allowed)
- Current smokers
- Diabetes mellitus type 1 and type 2 as defined by current or previous treatment with antidiabetic medications of any kind or HbA1c ≥ 48mmol/mol
- Severe hepatic disease (Alanine transferase \> 3 x UNL)
- Severe impaired renal function (eGFR \< 30ml/min)
- Congestive heart disease New York Heart Association (NYHA) class 3-4
- History of acute or chronic pancreatitis
- History of cholecystitis or cholecystolithiasis
- Pregnant or breastfeeding women
- Known bronchial asthma or interstitial lung disease
- Family history of multiple endocrine neoplasia type 2 (MEN2) or medullary thyroid carcinoma
- Large goiter or plasma-calcitonin \> 50ng/ml
Key Trial Info
Start Date :
January 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 31 2020
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT03466021
Start Date
January 1 2018
End Date
May 31 2020
Last Update
March 16 2021
Active Locations (2)
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1
Hospital of South West Jutland
Esbjerg, Denmark, 6700
2
Lillebaelt Hospital
Vejle, Denmark, 7100