Status:
TERMINATED
The Role of Hypoxia as a Selective Pressure for TP53 Mutations
Lead Sponsor:
Institute of Cancer Research, United Kingdom
Collaborating Sponsors:
Cancer Research UK
Conditions:
Endometrial Cancer
Eligibility:
FEMALE
18+ years
Brief Summary
The study aims to develop scans that tell the investigators about the oxygen content of tumours using Magnetic Resonance Imaging (MRI) and seeing whether regions of low oxygen content are related to m...
Detailed Description
Cancer tissue harbours a multitude of genetic alterations, and it is well-established that when certain key alterations develop, they are powerful determinants of tumour behaviour (growth rate, potent...
Eligibility Criteria
Inclusion
- ≥18 years of age on the day of signing the informed consent.
- Histologically confirmed endometroid or serous endometrial cancer.
- Scheduled to have hysterectomy at the cancer centre
- Identifiable tumour mass on staging MRI.
- Voluntarily agreed to participate by giving written informed consent.
Exclusion
- Life expectancy of \< 6 months.
- Ferromagnetic implants, contraindicating MRI
- Claustrophobia so unable to tolerate MRI
- Unable to lie flat
- Ascites sufficient to prevent patient being fitted in the scanner bore
- Histology unlikely to show variation in TP53 status, or heavily calcified disease.
- Radiotherapy to the abdomen or pelvis within 6 months of the screening visit.
- Unresolved bowel obstruction.
- Currently participating or has participated in a study with an investigational compound or device within 30 days of the start of treatment.
- History or current evidence of any condition, therapy, or lab abnormality that might confound the results of the study, interfere with patient's participation for the full duration of the study, or is not in the best interest of the patient to participate.
- Unlikely to comply with the requirements of the study.
Key Trial Info
Start Date :
February 6 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 30 2019
Estimated Enrollment :
5 Patients enrolled
Trial Details
Trial ID
NCT03466034
Start Date
February 6 2018
End Date
July 30 2019
Last Update
January 29 2020
Active Locations (1)
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1
The Institute of Cancer Research & The Royal Marsden NHS Foundation Trust
Sutton, Surrey, United Kingdom, SM2 5PT