Status:
COMPLETED
Anti-Angiotensin II Type 1 Receptor Antibodies and Kidney Transplant Outcomes
Lead Sponsor:
Paris Translational Research Center for Organ Transplantation
Collaborating Sponsors:
Center for Cardiovascular Research Berlin
Conditions:
Kidney Transplant Failure and Rejection
Eligibility:
All Genders
18+ years
Brief Summary
Incompatibility between non-genetically identical donors and recipients has been increasingly recognized as the main contributing factor to solid allograft rejection and failure, through the triggerin...
Detailed Description
The aims of this study are: 1. To assess the incidence of post-transplant anti-angiotensin II type 1 receptor antibodies within the first year after transplantation in an unselected population of kid...
Eligibility Criteria
Inclusion
- Kidney recipient transplanted between January 1, 2008 and December 31, 2012
- Kidney recipient over 18 years of age
- Simultaneous histological and serological assessment within the first year after transplantation, including i) kidney allograft biopsy, ii) assessment of donor-specific anti-HLA antibodies, and available stored serum for anti-angiotensin II type 1 receptor antibody assessment
Exclusion
- No simultaneous histological and serological assessment within the first year after transplantation, including i) absence of serum available for anti-angiotensin II type 1 receptor antibody assessment, and/or ii) absence of donor-specific anti-HLA antibody testing, and/or iii) absence of kidney allograft biopsy
- Inadequate kidney allograft biopsy according to the Banff classification for allograft rejection
- Combined transplantation
Key Trial Info
Start Date :
January 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2017
Estimated Enrollment :
1845 Patients enrolled
Trial Details
Trial ID
NCT03466775
Start Date
January 1 2008
End Date
December 31 2017
Last Update
March 15 2018
Active Locations (2)
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1
Kidney Transplant Department, Saint-Louis Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France
Paris, France, 75010
2
Kidney Transplant Department, Necker Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France
Paris, France, 75015