Status:
RECRUITING
PUMA (Paediatric Osseous Marrow Assessment)
Lead Sponsor:
Institute of Cancer Research, United Kingdom
Conditions:
Leukaemia
Eligibility:
All Genders
5-24 years
Brief Summary
This is a pilot cancer imaging study investigating change in the apparent diffusion coefficient (ADC) at a single time point post-transplantation in patients. The treatment is bone marrow transplant a...
Detailed Description
This is a single-center pilot study. The investigators intend to image 12 inpatients, aged 5-24 years old who are scheduled for haemopoietic stem cell transplantation. Patients will have two MRI scan...
Eligibility Criteria
Inclusion
- All patients with relapsed or high risk acute lymphoblastic or myeloblastic leukaemia planned for haemopoietic stem cell transplantation
- Cooperative paediatric individuals and young adults (5-24-years-old) not requiring general anaesthesia or sedation for the purpose of MRI
- Able to lie flat throughout the scan
Exclusion
- Non cooperative patients
- Ferromagnetic implants, contraindicating MRI
- Claustrophobia
- Unable to lie flat throughout the scan
- Uncertain histological diagnosis
- Musculoskeletal disorders
- Metabolic disorders
- Lack of signed parental consent and patient's verbal approval
Key Trial Info
Start Date :
March 5 2018
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2025
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT03466944
Start Date
March 5 2018
End Date
May 1 2025
Last Update
May 1 2024
Active Locations (1)
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1
The Institute of Cancer Research and Royal Marsden NHS Foundation Trust
Sutton, Surrey, United Kingdom, SM2 5PT