Status:
UNKNOWN
Multicenter Study of Impulse Oscillometry in Chinese
Lead Sponsor:
Guangzhou Institute of Respiratory Disease
Collaborating Sponsors:
Beijing Hospital
Beijing Children's Hospital
Conditions:
Healthy Subjects
Chronic Obstructive Pulmonary Disease
Eligibility:
All Genders
4-95 years
Brief Summary
The purpose of this study is to establish the reference values of impulse oscillometry (IOS) in healthy Chinese, and compare the indices of IOS in patients with lung disease, such as chronic obstructi...
Eligibility Criteria
Inclusion
- Inclusion Criteria for healthy subjects:
- life-long non-smokers
- no symptoms and history of chronic cardiopulmonary diseases (chronic bronchitis, asthma, lung cancer, pulmonary fibrosis, pulmonary tuberculosis, chronic heart diseases, etc.)
- no abnormal findings on physical examination
- written informed consent was obtained
- Inclusion Criteria for COPD:
- Diagnosis of chronic obstructive pulmonary disease (COPD), as classified by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines and post-bronchodilator FEV1/FVC (forced vital capacity) \< 70%.
- Inclusion Criteria for asthma:
- Diagnosis of asthma, as classified by national and international asthma guidelines.
- Inclusion Criteria for ILD:
- ILD diagnosis confirmed by lung biopsy, X ray or BALF analysis.
- Inclusion Criteria for UAO:
- Diagnosis of UAO.
- Exclusion Criteria for healthy subjects:
- upper or lower respiratory infection within 4 weeks
- long-term exposure to harmful gas or particles
- using β-blocker for treatment
- pregnant women, epileptic
- other diseases or surgeries potentially affecting lung function
Exclusion
Key Trial Info
Start Date :
September 1 2016
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2018
Estimated Enrollment :
4000 Patients enrolled
Trial Details
Trial ID
NCT03467880
Start Date
September 1 2016
End Date
December 1 2018
Last Update
March 16 2018
Active Locations (2)
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1
Beijing Hospital
Beijing, China, 100005
2
State Key Laboratory of Respiratory Disease,China Clinical Research Center of Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University
Guangzhou, China, 510120