Status:
COMPLETED
Influence of Open and Laparoscopic Abdominal Surgery Involving the Intestinal Tract on Serum 1,3-ß-D-Glucan (BDG) Values
Lead Sponsor:
Medical University of Graz
Collaborating Sponsors:
Barmherzige Brueder Marschallgasse / Graz
Conditions:
Invasive Candidiases
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Candida species are both known to colonize physiologically mucosal surfaces in the human body without causing signs or symptoms of infection and to cause a wide variety of diseases, including mucocuta...
Eligibility Criteria
Inclusion
- Elective open abdominal surgery involving the small and/or large colon and with surgical sectioning of intestinal mucosa
- Signed informed consent
Exclusion
- Ongoing antifungal therapy for treatment of active fungal infection or antifungal therapy within 4 weeks prior to inclusion
- Antibiotic therapy other than optional single shot surgical prophylaxis as clinically indicated
- Ongoing Enterococcus sp. bacteremia or treatment of Enterococcus sp. bacteremia within 4 weeks prior to inclusion
- Clinical or radiological or laboratory evidence of current infectious disease (i.e. temperature \>38°C, elevated C-reactive protein (CRP) \>5mg/dl, leukocytosis \>11400/μl, elevated neutrophiles \>78%) as assessed by the treating physician
- Immunoglobulin, blood or blood products (i.e. thrombocytes, fresh frozen plasma) administration within 4 weeks prior to inclusion
- Abdominal surgery (laparoscopic or open) or other major surgeries (e.g. aortocoronary bypass) within 4 weeks prior to inclusion
- Subsequent invasive candidiasis (defined according to proposed European Organization for Research and Treatment of Cancer Mycoses study group \[EORTC/MSG\] definitions of fungal infections in ICU) or other complicating infectious disease after surgery within the 5 day observation time frame
Key Trial Info
Start Date :
March 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 17 2019
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT03468803
Start Date
March 1 2018
End Date
January 17 2019
Last Update
March 21 2019
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Medical University of Graz
Graz, Stmk, Austria, 8036