Status:
RECRUITING
rTMS for Craving in Methamphetamine Use Disorder
Lead Sponsor:
Oregon Health and Science University
Conditions:
Methamphetamine Abuse
Substance Use Disorders
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The primary aim of this project is to use a randomized single-blind sham-controlled study to investigate if high frequency repetitive transmagnetic stimulation (HF-rTMS) can modulate cue-induced cravi...
Eligibility Criteria
Inclusion
- Subjects must use at least 0.5 g per day at least 5 days per week and have a minimum 12-month history of METH abuse.
- Subjects must meet DSM V diagnosis for methamphetamine use disorder.
- Subjects must have a minimum 4-week period of detoxification and a desire to stop using methamphetamine.
Exclusion
- Present or past history of neurological disorder
- The present history of a DSM IV Axis I or DSM V primary psychiatric disease (apart from MUD and depressive symptoms defined as a Hamilton Depression Scale Score \< 7 ("normal"))
- Scores on the Hamilton Depression Scale \> 8, possibly indicating clinical depression
- No current abuse of drugs other than methamphetamine (except nicotine). Urine-screening tests for psychoactive drugs will be performed to corroborate the lack of drug use.
- Individuals meeting criteria for cannabis use disorder or alcohol use disorder
- Medical illness that can affect brain function
- Past or present history of cardiovascular disease or high blood pressure
- Any history of epilepsy or a known history of seizure disorder
- A history of metal in the head or chest area (except dental fillings or braces)
- Current consumption of psychiatric medication
- Any other medical, neurological or neurosurgical condition that would preclude the administration of repetitive transmagnetic stimulation
Key Trial Info
Start Date :
February 7 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2025
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT03470480
Start Date
February 7 2018
End Date
September 1 2025
Last Update
May 17 2024
Active Locations (1)
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1
Veterans Affairs Portland Health Care System
Portland, Oregon, United States, 97239