Status:
RECRUITING
Pioglitazone to Reduce Sympathetic Overactivity in CKD Patients
Lead Sponsor:
The University of Texas at Arlington
Collaborating Sponsors:
University of Texas, Southwestern Medical Center at Dallas
Conditions:
Chronic Kidney Diseases
Eligibility:
All Genders
35-70 years
Phase:
PHASE4
Brief Summary
Chronic kidney disease (CKD) is associated with a higher risk of cardiovascular disease and death. An overactive sympathetic nervous system in CKD patients is one of the major mechanisms increasing th...
Detailed Description
Chronic Kidney Disease (CKD) is a major health problem affecting more than 26 million Americans. Notably, more patients with CKD die of cardiovascular complications than progress to dialysis. An overa...
Eligibility Criteria
Inclusion
- CKD patients classified as Stage 3 and 4 of National Kidney Foundation Classification with estimated glomerular filtration rate (GFR) between 15 and 59 mL/min/1.73 m2 according to the Modification of Diet in Renal Disease (MDRD) formula based on serum creatinine, age, gender, and race.
- Men and women 35 to 70 years of age
Exclusion
- Allergy to Glitazones
- Myocardial infarction
- Heart failure
- Angina
- History of kidney stones
- Liver disease (abnormal liver enzymes)
- Anemia (hemoglobin \<8 g/dl)
- Cancer with current treatment
- Previous organ transplantation
- Immunosuppressant therapy
- Human immunodeficiency virus infection
- Pregnancy or lactating
- Current tobacco use
- Dilantin and oral contraceptive usage due to potential drug interaction with glitazones
- Self-identified history of hypoglycemia
Key Trial Info
Start Date :
April 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2026
Estimated Enrollment :
28 Patients enrolled
Trial Details
Trial ID
NCT03471117
Start Date
April 1 2018
End Date
April 1 2026
Last Update
June 10 2025
Active Locations (2)
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1
University of Texas at Arlington
Arlington, Texas, United States, 76010
2
UT Southwestern
Dallas, Texas, United States, 75390