Status:
TERMINATED
EXOme Rare Cancers in Children (EXOCARE)
Lead Sponsor:
University Hospital, Angers
Conditions:
Predisposition, Genetic
Cancer Childhood
Eligibility:
All Genders
Phase:
NA
Brief Summary
Other than high-dose radiation and previous chemotherapy, few strong risk factors have been identified as causes of childhood cancer. Geneticists estimate that 5 to 10% of all cancers diagnosed during...
Detailed Description
-Primary objective : Our aim is to identify new mutations and genes involved in paediatric cancer predisposition associating developmental delay by WES of a sub-cohort of patients included in the TED ...
Eligibility Criteria
Inclusion
- For "Patient cancer" :
- Child having developed a cancer combined with a delay of development and\\or an intellectual deficiency before the age of 18 years and followed for a cancer of the child in one of hospital center of the Société Française de lutte contre les Cancers et les leucémies de l'Enfant et de l'adolescent (SFCE)
- At least a parent still alive and available to make genetic analyses
- For "Parent of cancer patient" :
- Parent whose child meets the criteria of inclusion of "Cancer patient"
Exclusion
- For "Cancer patient" :
- Genetic predisposition already identified at the child
- Absence of histological confirmation
- Child died without DNA of the available germinal lineage
- For "Parent of cancer patient" :
- Parent whose child doesn't meets the criteria of inclusion of "Cancer patient"
Key Trial Info
Start Date :
November 13 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 22 2024
Estimated Enrollment :
169 Patients enrolled
Trial Details
Trial ID
NCT03472807
Start Date
November 13 2019
End Date
February 22 2024
Last Update
March 17 2025
Active Locations (27)
Enter a location and click search to find clinical trials sorted by distance.
1
University Hospital of Amiens
Amiens, France
2
University Hospital of Angers
Angers, France
3
Cancer Center Bergonie Institut
Bordeaux, France
4
University Hospital of Bordeaux
Bordeaux, France