Status:
TERMINATED
MRI of Lung Structure and Function in Preterm Children
Lead Sponsor:
The Hospital for Sick Children
Conditions:
Bronchopulmonary Dysplasia
Eligibility:
All Genders
6-9 years
Brief Summary
The MRI tools developed by the investigators are well positioned for assessing regional changes in lung structure and function in preterm children with bronchopulmonary dysplasia (BPD), in which airwa...
Detailed Description
Briefly, at the beginning of an approximate three hour study visit, the qualified investigator (QI) / delegate will explain the study procedure to the participants and the participants will have an op...
Eligibility Criteria
Inclusion
- \- Children born pre-term at less than 28 weeks' gestation, currently aged 6-9 years, with and without BPD will be included.
- For the preterm non-BPD cohort, inclusion will include
- no requirement of supplementary oxygen beyond 28 days from birth. For the BPD preterm cohort, inclusion criteria will include
- need for oxygen at 36 weeks' postmenstrual age, which includes those with moderate-severe disease .
- For the healthy cohort, inclusion will include
- absence of any diagnosed pulmonary disease and term birth.
Exclusion
- Children with
- known interstitial lung disease, congenital lung anomalies, cystic fibrosis, ciliary dysfunction, immunodeficiency, neuromuscular disease or structural heart disease, which may have associated pulmonary function tests (PFT) and/or MRI findings;
- genetic syndromes which may have other associated structural lung anomalies;
- any contraindications for MRI
- severe neurosensory deficits which would prevent test completion;
- viral or bacterial respiratory infection within 6 weeks will be excluded. For all three groups (healthy, preterm non-BPD and preterm BPD), we will exclude
- those with congenital lung disease (i.e. Congenital diaphragmatic hernia (CDH), lung cysts) or non BPD acquired chronic lung disease as defined by need for any routine supplementary oxygen
- if the participant has an MRI incompatible device or any metal in their body which cannot be removed, including but not limited to pacemakers, neurostimulators, biostimulators, implanted insulin pumps, aneurysm clips, bio prosthetic, artificial limb, metallic fragment or foreign body, shunt, surgical staples (including clips or metallic sutures and/or ear implants).
Key Trial Info
Start Date :
September 1 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 8 2019
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT03475264
Start Date
September 1 2018
End Date
October 8 2019
Last Update
August 1 2025
Active Locations (1)
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1
The Hospital for Sick Children
Toronto, Ontario, Canada, M5G 1X8