Status:
COMPLETED
Effects of Gastric Bypass Surgery on Bile Acid Homeostasis
Lead Sponsor:
Hvidovre University Hospital
Collaborating Sponsors:
University of Copenhagen
Conditions:
Obesity
Eligibility:
All Genders
25-65 years
Brief Summary
The purpose of this study is to determine whether the bile acid circulation is changed after gastric bypass surgery. Further, to account for how the changed anatomy of the gut influences how the bile ...
Eligibility Criteria
Inclusion
- Age between 25 and 65 years
- For patients: uncomplicated Roux-en-Y Gastric Bypass surgery more than 12 months before study initiation
- For controls: Age, BMI and gender matched with patient group
Exclusion
- Previous removal of gall bladder or other abdominal surgeries except appendectomy (and gastric bypass surgery for patient group)
- Known liver disease or thyroid disease requiring antithyroid medication
- Chronic gastrointestinal symptoms
- Any chronic disease interfering with, or susceptive of interfering with appetite or gastrointestinal function
- Any medication interfering with, or susceptive of interfering with appetite or gastrointestinal function
- Smoking within the last month
- Alcohol consumption above 168 grams per week
- Currently pregnant or breast-feeding
- Anaemia with haemoglobin \<6,5 mmol/L (\<117 mg/dl)
- Loss or gain of more than 3 kg within the last 3 months
Key Trial Info
Start Date :
September 1 2016
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2017
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT03475849
Start Date
September 1 2016
End Date
June 1 2017
Last Update
March 23 2018
Active Locations (1)
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1
Department of Endocrinology at Hvidovre University Hospital
Hvidovre, Copenhagen, Denmark, DK-2650