Status:
COMPLETED
Relationship Between Dopaminergic Asymmetric Degeneration and Attentional Resources in Parkinson's Disease.
Lead Sponsor:
Ospedale Generale Di Zona Moriggia-Pelascini
Conditions:
Parkinson Disease
Attention Disturbances
Eligibility:
All Genders
40-85 years
Phase:
NA
Brief Summary
The researchers aimed to investigate the relationship between the asymmetric dopaminergic degeneration and the attentional resources in a group of patients with Parkinson's disease (PD).
Detailed Description
To bypass the impaired habitual motor-behavioural control, Parkinson's disease (PD) patients may exploit the network of goal-directed mode of action. The frontostriatal connections underline this func...
Eligibility Criteria
Inclusion
- Stage 2.5-3 according to the Hoehn and Yahr scale (H\&Y);
- Stable pharmacological treatment for the last 6 weeks before the enrolment and during the hospitalization;
- Mini Mental State Examination (MMSE) ≥ 24;
- No evidences of dysexecutive syndrome.
Exclusion
- Any focal brain lesion detected in brain imaging studies (CT or MRI) performed in the previous 12 months;
- Drug-induced dyskinesias;
- Disturbing resting and/or action tremor, corresponding to scores 2-4 in the specific items of UPDRS III;
- Behavioral disturbances (evaluated with Neuropsychiatric Inventory);
- Visual and auditory dysfunctions according to the general clinical evaluation and medical history;
- Equivocal report about the side of disease onset or bilateral motor involvement.
Key Trial Info
Start Date :
January 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2017
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT03476668
Start Date
January 1 2017
End Date
August 1 2017
Last Update
May 30 2018
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