Status:
COMPLETED
Prevention of Cardiovascular Stiffening With Aging and Hypertensive Heart Disease
Lead Sponsor:
University of Texas Southwestern Medical Center
Conditions:
Lv Hypertrophy
Heart Failure, Diastolic
Eligibility:
All Genders
40-64 years
Phase:
NA
Brief Summary
The purpose of this study is to determine whether vigorous exercise training 4-5 days/week for one year in sedentary middle aged (ages 40-64) individuals at high risk for future development of heart f...
Detailed Description
The global objective of this project is to test novel strategies to prevent diastolic dysfunction associated with HFpEF; these include: a) identifying high risk individuals by using population derived...
Eligibility Criteria
Inclusion
- Presence of left ventricular hypertrophy (by MRI, echocardiography or ECG)
- Normal ejection fraction (\>50%)
- Elevated cardiac biomarker (high sensitivity troponin, NT-BNP)
Exclusion
- age \< 40 or \>64
- body mass index\>35
- history of heart failure, myocarditis, restrictive cardiomyopathy, severe chronic obstructive pulmonary disease, unstable coronary artery disease or recent (\<12 month) acute coronary syndrome, cerebrovascular disease as evidenced by prior transient ischemic attack or stroke and active/recent tobacco use (quit \< 5 years).
- chronic orthopedic injury that precludes exercise testing
Key Trial Info
Start Date :
June 1 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 2 2019
Estimated Enrollment :
56 Patients enrolled
Trial Details
Trial ID
NCT03476785
Start Date
June 1 2015
End Date
July 2 2019
Last Update
October 14 2019
Active Locations (1)
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1
The Institute for Exercise and Environmental Medicine
Dallas, Texas, United States, 75231