Status:
TERMINATED
Pragmatic Prehospital Group O Whole Blood Early Resuscitation Trial
Lead Sponsor:
Jason Sperry
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Hemorrhagic Shock
Eligibility:
All Genders
18-89 years
Phase:
PHASE3
Brief Summary
Despite advances in trauma resuscitation, a paucity of therapeutic interventions are available early enough to reduce the downstream morbidity and mortality attributable to hemorrhage, shock and coagu...
Detailed Description
Traumatic injury represents an incredible health care burden in the United States and worldwide. Hemorrhage is estimated to be responsible for over 40% of all trauma-related deaths. Ongoing traumatic ...
Eligibility Criteria
Inclusion
- Injured patients being transport via an air medical service with hypotension (SBP =/\< 90mmHg with tachycardia \>108 OR SBP=/\<70 without the tachycardia requirement)
Exclusion
- Age \< 18 or \> 89 years
- Isolated fall from standing injury mechanism
- Brain matter exposed or penetrating brain injury (GSW)
- CPR \> 5 mins with out ROSC
- Isolated burns without evidence of traumatic injury
- Isolated Drowning or Hanging
- No Intravenous or Intraosseous access
- Known prisoner or known pregnancy
- Referral Hospital Admission
- Wearing No PPOWER bracelet
- Objection to study voiced by subject or family at scene
Key Trial Info
Start Date :
November 20 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 30 2020
Estimated Enrollment :
86 Patients enrolled
Trial Details
Trial ID
NCT03477006
Start Date
November 20 2018
End Date
October 30 2020
Last Update
October 6 2021
Active Locations (1)
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1
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213