Status:
COMPLETED
Evaluation of 2 Techniques of Apheresis to Desensitize ABO Incompatible Kidney Transplant Candidates
Lead Sponsor:
University Hospital, Toulouse
Conditions:
Kidney Transplantation
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Kidney transplantation is the treatment of choice for end-stage renal disease. ABO incompatible (ABOi) living donor kidney transplantation is one of the best ways to expand the donors' pool. However, ...
Detailed Description
All recipients will receive an induction therapy with rituximab and polyclonal antibodies, as well as a maintenance therapy by tacrolimus, mycophenolic acid (switched for mTOR (Mechanistic target of r...
Eligibility Criteria
Inclusion
- Patient eligible for living donor ABO incompatible kidney transplantation
- Presenting an IsoAgglutinin immunoglobulin G titer (anti-A-B) between 1/8 and 1/128, before desensitization
- Patient older than 18 years
- Women of childbearing age must have a pregnancy test before starting the study and undergoing study. They must take an effective and acceptable method of contraception before starting the study and throughout the study period. Sexually active men should use a condom throughout the course of the study
- Patient able to sign an informed consent form
- Patient affiliated with a social security scheme
Exclusion
- Presence of anti-HLA (Human Leucocyte Antigens) allo-antibodies
- Patient with comorbidities that prevent desensitization protocols
- Women who are pregnant, or who may become pregnant or breastfeeding women
- History of hypersensitivity related to a component of the apheresis membrane
- Subjects under legal protection
- Subjects participating in another interventional research protocol or in an exclusion period from another interventional research protocol
Key Trial Info
Start Date :
May 2 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 3 2023
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT03477656
Start Date
May 2 2018
End Date
October 3 2023
Last Update
April 12 2024
Active Locations (1)
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1
University Hospital Toulouse (Hospital Rangueil)
Toulouse, France, 31059