Status:
ACTIVE_NOT_RECRUITING
Coronary Microvascular Function and CT Coronary Angiography (CorCTCA)
Lead Sponsor:
NHS National Waiting Times Centre Board
Collaborating Sponsors:
University of Glasgow
British Heart Foundation
Conditions:
Angina, Stable
Angina Pectoris, Variant
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Angina in patients without obstructive coronary artery disease (CAD) is a clinical conundrum and patient management is heterogeneous. Hypothesis: Abnormal coronary function is common and clinically re...
Detailed Description
According to information provided by the British Heart Foundation, there are approximately 2.3 million men and women living with angina in the United Kingdom (UK). In 2014, there were \~247,363 corona...
Eligibility Criteria
Inclusion
- Symptoms of angina or angina-equivalent informed by the Rose Angina questionnaire.
- Intermediate or no obstructive coronary disease i.e. no coronary stenosis \>70% in an artery \>2.5 mm, as revealed by CT coronary angiography.
Exclusion
- A health problem that would explain the angina, e.g. anaemia, moderate-severe aortic stenosis, hypertrophic obstructive cardiomyopathy
- Obstructive disease evident in a coronary artery (diameter \>2.5 mm), i.e. \>50 - 70% circumferential plaque extending for ≥2 coronary segments, or a stenosis\>70% as revealed by CT coronary angiography
- Lack of informed consent.
- Exclusion from randomisation in the catheter laboratory:
- Flow-limiting coronary disease defined by a fractional flow reserve (FFR) ≤0.80 in an artery\>2.5 mm.
Key Trial Info
Start Date :
August 31 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 31 2033
Estimated Enrollment :
250 Patients enrolled
Trial Details
Trial ID
NCT03477890
Start Date
August 31 2017
End Date
August 31 2033
Last Update
October 29 2024
Active Locations (3)
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1
Golden Jubilee National Hospital
Clydebank, Dunbartonshire, United Kingdom, G814DY
2
Forth Valley Royal Hospital
Larbert, Forth Valley, United Kingdom, FK5 4WR
3
Glasgow Royal Infirmary
Glasgow, Strathclyde, United Kingdom, G4 0SF