Status:
COMPLETED
Interactions Between Striatum and Cerebellum in ADCY5 and PRRT2 Dystonias
Lead Sponsor:
Institut National de la Santé Et de la Recherche Médicale, France
Conditions:
Dystonia
Eligibility:
All Genders
15-60 years
Phase:
NA
Brief Summary
The investigators will study the relationship between the basal ganglia and the cerebellum in dystonia by associating cerebellar stimulations with functional magnetic resonance imaging analysis.
Detailed Description
Although dysfunctions in both basal ganglia and cerebellum in dystonia are well documented, the functional relationships between these two important motor control networks remains unclear in the conte...
Eligibility Criteria
Inclusion
- clinical diagnosis of Dystonia
- characterized ADCY5 or PRRT2 mutation
- must have a European Social Security card or a parent having an European Social Security card
- must be older than \> 15 years 3 months
- must be able to give informed consent or, for minor patients, parents must be able to give informed consent
- must be able to comply with all study procedures, based on the judgment by the investigator(s).
Exclusion
- major depression or any major mental disorders (axis I disorders)
- neurologic disorder other than dystonia
- presence of pacemaker, intracardiac lines, implanted pumps or stimulators, or metal objects inside the eye or skull, cochlear implant
- Permanent makeup of lips or eyelids
- Black large tattoo close to the head
- Severe claustrophobia
- Current pregnancy or breast feeding
- Copper intrauterine device Subjects with one of the following exclusion criteria will not receive cerebellar stimulation
- Open scalp wounds or scalp infection,
- epilepsy or seizures
- Taking at the time of the study: ketamine, antidepressants, ganciclovir, ritonavir, amphetamines, antiemetic.
Key Trial Info
Start Date :
August 6 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 4 2024
Estimated Enrollment :
104 Patients enrolled
Trial Details
Trial ID
NCT03481491
Start Date
August 6 2018
End Date
August 4 2024
Last Update
November 18 2025
Active Locations (1)
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1
Département de Neurologie, Fédération des Maladies du Système Nerveux, GH Pitié-Salpêtrière, 47 Bd de l'Hôpital
Paris, France